Oxytocin Administration in BDD and OCD

Completed · Phase 2 · Has a placebo group

Conditions studied: Body Dysmorphic Disorder, Obsessive-compulsive Disorder

In brief

The purpose of the current study is to investigate the effect of an acute administration of intranasal oxytocin, relative to placebo, on social cognitive impairments among individuals with body dysmorphic disorder and obsessive-compulsive disorder, compared to healthy controls.

Key facts

Study ID

NCT02671266

Run by

Massachusetts General Hospital

People needed

41

Starts

2014-12-01

Expected to finish

2017-10-01

Last updated by the study team

2018-11-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Treatment-seeking adult males and females ≥ 18 years of age
• Meets DSM-IV criteria for principal BDD (for BDD group) or principal OCD (for OCD group), as determined by Structured Clinical Interview for DSM-IV (SCID) diagnostic interview
• For females only: must be taking low-dose oral contraceptive pills, as defined by monophasic pills containing <50 mcg ethinyl estradiol
• For healthy volunteers only: does not meet current DSM-IV diagnosis of any Axis I disorder

You may not qualify if…

• Participants in the BDD group will be excluded if they have a comorbid diagnosis of OCD and participants in the OCD group will be excluded if they have a comorbid diagnosis of BDD.
• Current diagnosis of schizophrenia, psychotic disorder, bipolar disorder, substance abuse or substance dependence. All other Axis I comorbidities will be permitted to foster the accrual of a clinically relevant sample.
• Significant nasal pathology (e.g., atrophic rhinitis, history of hypophysectomy, recurrent nosebleeds)
• Smokers who smoke ≥ 15 cigarettes daily
• Serious medical illnesses
• Active homicidal or suicidal ideation
• Concurrent use of psychotropic medications
• Steroid or hormone use (except low-dose oral contraceptive pills for females, which is allowed)
• For females only: positive urine pregnancy test and use of high dose estrogen/progestin pills (low dose estrogen/progestin oral contraceptives will be allowed due to stability of hormone levels during active phase)
• For healthy volunteers only: any current DSM-IV Axis I disorder

Where it is running

• Massachusetts General Hospital/Harvard Medical School — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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