Splanchnic Nerve Anesthesia in Heart Failure
Completed · Not applicable
Conditions studied: Heart Failure
In brief
Patients admitted for acute heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac hemodynamic parameters. Subsequently, the subject will undergo a regional nerve block of the splanchnic nerves. Patients will remain in the catheterization lab for the duration of anesthetic block and will be continuously hemodynamically monitored. This study will be a prospective, uncontrolled clinical trial. The study will not be controlled as invasive monitoring of hemodynamics will be performed, allowing clear demonstration of a cause-effect relationship. The goal of the study is to provide proof of concept.
Key facts
- Study ID
- NCT02669407
- Run by
- Duke University
- People needed
- 14
- Starts
- 2017-01-01
- Expected to finish
- 2018-10-01
- Last updated by the study team
- 2019-12-06
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of heart failure (HF)
- Prior admissions for decompensated HF
- Symptomatic with dyspnea with clinical, radiographic or echocardiographic signs of fluid overload
- On a stable HF drug regimen prior to admission
- Anticipated hospital stay of at least 2 nights following catheterization procedure
You may not qualify if…
- Ongoing treatment with oral anticoagulation other than aspirin
- Immunosuppressive medications for solid organ transplant
- Acute MI (STEMI or NSTEMI) within 7 days
- Evidence of cardiogenic shock within 48 hours
- Systolic blood pressure < 90 mmHg or >180 mmHg
- Restrictive or constrictive cardiomyopathy
- Chronic kidney disease stage 3 or higher due to primary renal pathology
- Pregnancy
Where it is running
- Duke — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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