Trial of Toothpaste to Reduce Plaque and Inflammation

Completed · Not applicable

Conditions studied: Plaque, Inflammation

In brief

Dental plaque causes caries and periodontal disease and data are sparse about toothpaste and plaque removal. Inflammation, caused by dental plaque, is a risk factor for cardiovascular disease. (CVD) The availability of (Plaque HD (TM), a plaque identifying toothpaste with targetol technology (TM)), afforded the unique opportunity to test whether there were statistically significant and clinically important reductions in plaque and inflammation in a randomized trial of apparently healthy individuals.

Key facts

Study ID

NCT02666508

Run by

University of Illinois at Chicago

People needed

61

Starts

2015-09-01

Expected to finish

2016-08-22

Last updated by the study team

2021-01-14

Who can join

Age: 19 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The inclusion criteria were as follows:
• Apparently healthy men and women age 19-45 with no history of CVD
• All 12 anterior teeth present (canine to canine in both upper and lower arches)
• English speaking
• Ability to commit to two 30 minute appointments These appointment must be 1 month apart)

You may not qualify if…

• • Student, faculty or staff with a clinical role at the University of Illinois College of Dentistry
• Individuals taking aspirin, other non-steroidal anti-inflammatory drugs or statins.
• Women who are pregnant or nursing
• Women taking birth control pills or using any hormone released birth control device
• Women on hormone replacement therapy
• Individuals who have taken antibiotics within two weeks of data collection appointment
• Individuals experiencing xerostomia
• Individuals who have experienced an illness, infection or tissue injury within two weeks of data collection appointment
• Individuals with arthritis, lupus or other chronic inflammatory conditions or syndromes
• Individuals with allergies to dyes or over the counter products
• Individuals who have missing anterior teeth, fixed or removable appliances or visible decay or staining in the anterior region (canine to canine in both upper and lower arches)
• Individuals whom have had a dental prophylaxis within 30 days of the data collection visit
• Individuals who have had a new restoration placed (anywhere in the oral cavity) within 30 days of the data collection visit

Where it is running

• UIC Clinical Research Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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