Pain Phenotypes in Knee Osteoarthritis

Completed

Conditions studied: Osteoarthritis, Knee, Pain

In brief

Recently, the medical community has learned damage to the knee joint may be one of many possible reasons for pain in knee osteoarthritis. Psychological factors and other aspects of brain function seem to play an important role in the pain experience. Although research studies have examined these factors on an individual basis, no study has examined all of these factors in the same population. Furthermore, some measures of brain function- having to do with perception of the painful body part- have yet to be examined in knee osteoarthritis. The investigators plan to study many of these variables in a group of people with knee osteoarthritis, as well in some healthy controls (without knee pain), in order to establish the relative importance of these measures in contributing to pain, as well as validate new measures of perception in people with knee osteoarthritis. We also plan to use a statistical tool- known as latent profile analysis- to look at subgroups of knee osteoarthritis pain. The hypothesis is that different people experience pain in knee osteoarthritis for different reasons. This study will be the first study to use all of these different variables- which can be reproduced in a clinical setting- to look for different subgroups of knee osteoarthritis pain. Ultimately, the goal is to help clinicians better prioritize and target interventions to individual patients. The investigators believe this will lead to better outcomes and fewer treatment complications currently associates with pharmaceutical and surgical interventions that are widely used to treat knee osteoarthritis.

Key facts

Study ID

NCT02664896

Run by

University of Colorado, Denver

People needed

187

Starts

2013-04-01

Expected to finish

2016-05-01

Last updated by the study team

2016-06-16

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 50-85
• Diagnosed with Knee Osteoarthritis by a physician or by ACR clinical criteria

You may not qualify if…

• sensory dysfunction due to injury (i.e. known nerve damage)
• neurological diagnosis affecting sensory or motor function (e.g. stroke, Parkinson's Disease, multiple sclerosisetc.)
• Healthy Volunteers eligibility criteria:
• Age 50-85
• Do not possess knee osteoarthritis diagnosis
• do not have knee pain
• do not have a history major knee trauma or lower extremity trauma or surgery
• do not have any other pain condition

Where it is running

• University of Colorado Denver, Anschutz Medical Campus — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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