Immunoinflammatory Response in Post Cardiac Arrest Syndrome (PCAS)

Recruiting now

Conditions studied: Cardiac Arrest, Inflammation, Obesity, Hypoxic Ischemic Encephalopathy (HIE)

In brief

This is a prospective, observational study to investigate molecular mechanisms mediating the systemic inflammatory process, and changes to metabolism, and their impact on brain injury, survival, and functional outcomes after cardiac arrest. Investigators have shown that cardiac arrest induces changes in the numbers and properties of circulating immune cells, shifting the balance towards a pro-inflammatory phenotype and there is increased interest in the inflammatory pathways and the signaling mechanisms through which they are modulated. Participants will undergo blood sampling during 7 days following cardiac arrest, and analyses performed. Patient characteristics, clinical circumstances, and outcomes will be recorded and their associations with these inflammatory pathways characterized.

Key facts

Study ID

NCT02664831

Run by

MaineHealth

People needed

400

Starts

2016-01-01

Expected to finish

2028-01-01

Last updated by the study team

2025-07-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 18 years or older
• Admitted to the intensive care unit after cardiac arrest episode
• Unresponsive after resuscitation

You may not qualify if…

• Moribund / actively dying at the time of evaluation
• Informed consent cannot be obtained within 24 hours of resuscitation
• Hemoglobin less than 7.0 g/dL, active high-volume bleeding, or requiring a transfusion

Where it is running

• Maine Medical Center — Portland, Maine, United States (enrolling)

Full record on ClinicalTrials.gov

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