Mechanisms of Muscle Blood Flow Dysregulation and Exercise Intolerance in Chronic Kidney Disease

Stopped early · Not applicable

Conditions studied: Chronic Kidney Disease

In brief

Patients with chronic kidney disease (CKD) experience fatigue and exercise intolerance. Increased oxidative stress in CKD may be a contributing factor. The role of impaired muscle blood flow regulation has not been fully explored. The investigators hypothesize that functional sympatholysis is exaggerated in CKD and this is associated with increased oxidative stress. The investigators also hypothesize that exercise training will improve functional sympatholysis and oxidative stress

Key facts

Study ID

NCT02664519

Run by

University of Texas Southwestern Medical Center

People needed

32

Starts

2016-01-01

Expected to finish

2021-03-18

Last updated by the study team

2021-03-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normotensive adults
• CKD 2-3

You may not qualify if…

• Blood Pressure ≥140/90
• eGFR >60ml/min/1.73 m2 or eGFR <30ml/min/1.73 m2
• Any evidence of cardiopulmonary disease, left ventricular hypertrophy or systolic dysfunction by echocardiography.
• Diabetes mellitus or other systemic illness
• Pregnancy
• Any history of substance abuse or current cigarette use
• Any history of psychiatric illness
• History of malignancy

Where it is running

• University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.