A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular Disease

Stopped early · Phase 3

Conditions studied: Prostate Cancer

In brief

The purpose of this trial is to test if a marketed drug for advanced prostate cancer (FIRMAGON) can reduce the risk of cardiovascular complications as compared to another marketed drug for advanced prostate cancer (LUPRON DEPOT) in subjects with prostate cancer and cardiovascular disease.

Key facts

Study ID

NCT02663908

Run by

Ferring Pharmaceuticals

People needed

545

Starts

2016-04-19

Expected to finish

2021-03-29

Last updated by the study team

2022-06-29

Who can join

Age: any. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Advanced prostate cancer
• Indication to initiate androgen deprivation therapy (ADT)
• Predefined cardiovascular disease

You may not qualify if…

• Previous or current hormonal management of prostate cancer (unless terminated at least 12 months prior to trial)
• Acute cardiovascular disease in the previous 30 days

Where it is running

• Arizona Institute of Urology — Tucson, Arizona, United States
• Urological Associates of Southern Arizona — Tucson, Arizona, United States
• University of Arizona College of Medicine — Tucson, Arizona, United States
• Urology Associates, PA — Little Rock, Arkansas, United States
• Pacific Cancer Medical Center, Inc. — Anaheim, California, United States
• San Diego Clinical Trials — La Mesa, California, United States
• Clinical Trials Research — Lincoln, California, United States
• VA Greater Los Angeles Healthcare System — Los Angeles, California, United States
• University of California, Irvine Medical Center — Orange, California, United States
• Skyline Urology — Torrance, California, United States
• Innovative Clinical Research Institute — Whittier, California, United States
• Urology Center of Colorado — Denver, Colorado, United States
• Yale University — New Haven, Connecticut, United States
• Urologic Surgeons of Washington — Washington D.C., District of Columbia, United States
• San Marcus Research Clinic Inc — Miami, Florida, United States
• Mount Sinai Comprehensive Cancer Center — Miami Beach, Florida, United States
• Clinical Research Center of Florida — Pompano Beach, Florida, United States
• Florida Urology Partners — Tampa, Florida, United States
• Comprehensive Urologic Care — Lake Barrington, Illinois, United States
• Springfield Clinic LLP — Springfield, Illinois, United States
• Urology of Indiana LLC — Greenwood, Indiana, United States
• First Urology PSC — Jeffersonville, Indiana, United States
• Iowa Clinic — West Des Moines, Iowa, United States
• University of Kansas Medical Center Research Institute, Inc. — Kansas City, Kansas, United States
• Urology Center of Alabama PC — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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