A Trial of PF-07901800 (TTI-621) for Patients With Hematologic Malignancies and Selected Solid Tumors

Stopped early · Phase 1

Conditions studied: Hematologic Malignancies, Solid Tumor

In brief

Multicenter, open-label, phase 1a/1b trial of PF-07901800 (TTI-621) in subjects with relapsed or refractory hematologic malignancies and selected solid tumors.

Key facts

Study ID

NCT02663518

Run by

Pfizer

People needed

249

Starts

2016-01-28

Expected to finish

2022-11-23

Last updated by the study team

2024-05-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Known current central nervous system disease involvement or untreated brain metastases
• Allogeneic transplant within 30 days prior to the planned start of treatment or subjects with active graft-vs-host disease with the exception of Grade 1 skin involvement
• History of hemolytic anemia or bleeding diathesis

Where it is running

• City of Hope — Duarte, California, United States
• Freidenrich Center for Translational Research (CTRU) — Palo Alto, California, United States
• Stanford Cancer Institute — Palo Alto, California, United States
• Colorado Blood Cancer Institute — Denver, Colorado, United States
• Presbyterian/St.Luke's Medical Center — Denver, Colorado, United States
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States
• Mayo Clinic — Jacksonville, Florida, United States
• Moffitt Cancer Center Richard M Schulze Family Foundation Outpatient Center at McKinley Campus — Tampa, Florida, United States
• Moffitt Cancer Center — Tampa, Florida, United States
• Covance Biorepository — Greenfield, Indiana, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Hackensack Meridian Health John Theurer Cancer Center — Hackensack, New Jersey, United States
• Hackensack UMC — Hackensack, New Jersey, United States
• The John Theurer Cancer Center at Hackensack UMC — Hackensack, New Jersey, United States
• Memorial Sloan Kettering Cancer Center- Monmouth — Middletown, New Jersey, United States
• Memorial Sloan Kettering Cancer Center Westchester — Harrison, New York, United States
• Laura and Isaac Perlmutter Cancer Center at NYU Langone Health — New York, New York, United States
• Laura and Isaac Perlmutter Cancer Center at NYU Langone — New York, New York, United States
• NYU Investigational Pharmacy — New York, New York, United States
• NYU Langone Health (Tisch Hospital) — New York, New York, United States
• Memorial Sloan Kettering Cancer Center-Clinical Trails Office — New York, New York, United States
• Columbia Univeristy — New York, New York, United States
• Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care — New York, New York, United States
• Memorial Sloan Kettering Cancer Center Rockefeller Outpatient Pavillion — New York, New York, United States
• City of Hope National Medical Center — Duarte, California, United States

Full record on ClinicalTrials.gov

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