The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

Completed · Phase 4

Conditions studied: Headache

In brief

This study compares the efficacy of low dose Ketamine versus Compazine for the control of headache in patients presenting to the Emergency Department.

Key facts

Study ID

NCT02657031

Run by

University Medical Center of Southern Nevada

People needed

54

Starts

2016-03-17

Expected to finish

2017-03-21

Last updated by the study team

2017-12-11

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 to 65 years
• Temperature < 100.4° F
• Diastolic Blood Pressure <104 mm Hg
• Normal neurological exam and mormal mental status

You may not qualify if…

• Pregnant or breastfeeding.
• Meningeal signs are present
• Acute angle closure glaucoma is suspected.
• Head trauma within the previous two weeks
• Lumbar puncture within the previous two weeks
• Thunderclap onset of the headache
• Weight more than 150 kg or less than 40 kg.
• Known allergy to one of the study drugs.
• History of schizophrenia or bipolar disorder.
• History of intracranial hypertension.
• Is a prisoner
• Patient declined informed consent
• Non-English speaking patient.
• Attending provider excludes patient

Where it is running

• University Medical Center of Southern Nevada — Las Vegas, Nevada, United States

Full record on ClinicalTrials.gov

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