The Effects of Multi-focal tDCS on Motor-cognitive Dysfunctions in Parkinson's Disease
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Parkinson's Disease
In brief
The current RCT aims to establish the therapeutic potential of tDCS for freezing of gait (FOG) and motor-cognitive dysfunctions in PD. As noted, FOG is often unresponsive to pharmacological and other treatments, especially in the advanced stages of the disease. While it is likely that tDCS will provide symptomatic relief, we will also explore, via secondary outcomes, the potential for tDCS to modify disease progression. Support for this possibility stems from the likely mechanisms of action of tDCS.
Key facts
- Study ID
- NCT02656316
- Run by
- Tel-Aviv Sourasky Medical Center
- People needed
- 85
- Starts
- 2017-01-01
- Expected to finish
- 2020-01-01
- Last updated by the study team
- 2019-10-03
Who can join
Age: 25 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Inclusion criteria: patients diagnosed with PD, with Hoehn and Yahr Stage between 1-3.5, who suffer from FOG, as measured at screening by the previously validated new FOG questionnaire (NFOG-Q), whose medications have not changed within 1 month of the study and are not anticipated to change during the study, are able to walk independently, and who are between the ages of 40-80 inclusive.
You may not qualify if…
- Subjects who show no FOG during testing in the lab in response to a FOG provoking protocol, any diagnosed psychiatric or other neurological disorder, stroke, unbalanced and high blood pressure, pregnancy, participation in any clinical trial in the last three months, unwillingness to be randomized; implanted with deep brain stimulation, pacemakers, intracranial electrodes, implanted defibrillators or any other prosthesis; or a perceived inability to complete the study. Additional exclusion criteria related to tDCS safety will include a personal or family history of epilepsy, the use of neuro-active drugs, or risk of metal fragments in the eyes or head.
Where it is running
- Institute for Aging Research — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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