A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity

Completed · Not applicable

Conditions studied: Posttraumatic Stress Disorder, Depression, Alcohol-Related Disorders, Suicidal Ideation, Substance-Related Disorders, Mild Cognitive Impairment, Quality of Life, Pain, Wounds and Injury, Brain Injuries, Chronic Disease

In brief

The overarching goal of this UH2-UH3 proposal is to work with the NIH Health Care Systems Research Collaboratory to develop and implement a large scale, cluster randomized pragmatic clinical trial demonstration project that directly informs national trauma care system policy targeting injured patients with presentations of Posttraumatic Stress Disorder (PTSD) and related comorbidity. Each year in the United States (US), over 30 million individuals present to trauma centers, emergency departments, and other acute care medical settings for the treatment of physical injuries. Multiple chronic conditions including enduring PTSD, alcohol and drug use problems, depression and associated suicidal ideation, pain and somatic symptom amplification, and chronic medical conditions (e.g., hypertension, coronary artery disease, diabetes, and pulmonary diseases) are endemic among physical trauma survivors with and without traumatic brain injuries (TBI). Evidence-based, collaborative care/care management treatment models for PTSD and related comorbidities exist. These care management models have the potential to be flexibly implemented in order to prevent the development of chronic PTSD and depressive symptoms, alcohol use problems, and enduring physical disability in survivors of both TBI and non-TBI injuries; care management models may also be effective in mitigating the impact of the acute injury event on symptom exacerbations in the large subpopulation of injury survivors who already carry a substantial pre-injury burden of multiple chronic medical conditions.

Key facts

Study ID

NCT02655354

Run by

University of Washington

People needed

635

Starts

2015-10-01

Expected to finish

2019-11-01

Last updated by the study team

2021-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient currently admitted to inpatient/emergency department for a traumatic injury

You may not qualify if…

• Non-English speaking
• Self-inflicted injury
• Actively psychotic
• Incarcerated or in custody
• Less than 35 on PTSD Checklist
• Less than 3 items on PTSD medical record screen
• Less than 2 pieces of contact information

Where it is running

• Honor Health — Scottsdale, Arizona, United States
• Cedars Sinai — Beverly Hills, California, United States
• U.C. Davis — Sacramento, California, United States
• Santa Clara Valley Medical Center — San Jose, California, United States
• U.C.L.A. Harbor — Torrance, California, United States
• Hartford Hospital — Hartford, Connecticut, United States
• Georgia Regents — Augusta, Georgia, United States
• Eskenazi Health — Indianapolis, Indiana, United States
• University of Iowa — Iowa City, Iowa, United States
• University of Kentucky — Lexington, Kentucky, United States
• Louisiana State University — New Orleans, Louisiana, United States
• Regions Hospital — Saint Paul, Minnesota, United States
• University of Rochester — Rochester, New York, United States
• Jacobi Medical Center — The Bronx, New York, United States
• Wake Forest — Winston-Salem, North Carolina, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• Baylor Health Care System — Dallas, Texas, United States
• UT Southwestern Medical Center — Dallas, Texas, United States
• University of Texas Medical Branch at Galveston — Galveston, Texas, United States
• The University of Utah — Salt Lake City, Utah, United States
• The University of Vermont — Burlington, Vermont, United States
• Inova Trauma Center — Falls Church, Virginia, United States
• The University of Wisconsin Madison — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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