The Study of Skeletal Muscle Blood Flow in Becker Muscular Dystrophy

Stopped early · Early Phase 1

Conditions studied: Muscular Dystrophy

In brief

This pilot study tests the hypothesis that the medication nitric oxide extract from beetroot juice improves blood flow to the skeletal muscle during exercise. The investigators will use cutting edge technology with contrast enhanced ultrasound to visualize the microvascular blood supply to the forearm. Animal studies have shown reversal of muscle damage with improved delivery of blood to the exercising muscle. This research aims to understand the mechanism of action of this medication in a way it has never been studied before. The results may help benefit individuals with muscular Dystrophy in the future.

Key facts

Study ID

NCT02653833

Run by

Cedars-Sinai Medical Center

People needed

6

Starts

2017-11-01

Expected to finish

2018-09-01

Last updated by the study team

2020-01-14

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy man, aged 18 to 45 years, currently taking no medication. OR
• Clinical diagnosis of Becker Muscular Dystrophy (BMD), aged 18 to 45 years, and currently taking no medication.

You may not qualify if…

• Hypertension, diabetes, heart failure, liver disease
• ECG evidence of prolonged QT interval

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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