Utilization of TEG to Monitor Rivaroxaban Activity

Completed

Conditions studied: Anemia, Venous Thrombosis

In brief

The invesigators seek to devise a strategy for the assessment of Rivaroxaban activity in trauma and Emergency General Surgery (EGS) patients available as point-of-care testing. Thromboelastography (TEG) is a point of care, viscoelastic measurement of coagulation that is widely used in trauma and is viewed by many as superior to standard coagulation studies for the assessment of coagulopathy following injury and may be useful in detecting rivaroxaban effect in trauma and EGS patients to assess the degree of functional factor Xa impairment.

Key facts

Study ID

NCT02651909

Run by

Matthew Neal MD

People needed

100

Starts

2016-04-01

Expected to finish

2019-11-04

Last updated by the study team

2019-11-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Evidence of Rivaroxaban use with-in the last 48hours per medical records or report by patient, family, or other healthcare member familiar with patients drug medical history
• Willingness of subject or legally authorized representative to provide written consent for study procedures.

You may not qualify if…

• Known to be pregnant
• Known to be a prisoner
• Known Chronic liver disease
• Documented hypo coagulation condition (hemophilia, Von Willebrands, any congenital factor deficiency (V,X,XII) leukemia)
• Use of any anticoagulant medication other than Rivaroxaban (examples: Warfarin, lovenox, arixtra, fragmin, eliquis)
• Prehospital blood product administration (FFP, platelets, Prothrombin Complex Concentrate (PCC), tranexamic acid (TXA)
• Non-survivable traumatic brain Injury
• Comfort Measure Only (CMO) status

Where it is running

• University of Pittsburgh Medical Center, PUH, 200 Lothrop Street — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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