Mitochondrial Respiratory Function in Mammalian Skeletal Muscle

Stopped early

Conditions studied: Cancer, Cachexia

In brief

The purpose of this study is to determine whether skeletal muscle mitochondrial function is altered in patients with head and neck cancer compared to healthy controls.

Key facts

Study ID

NCT02650570

Run by

The University of Texas Medical Branch, Galveston

People needed

1

Starts

2017-02-14

Expected to finish

2017-03-29

Last updated by the study team

2017-10-26

Who can join

Age: 30 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women, aged 30-60 years.
• Diagnosed with advanced (stages III or IV), persistent (recurrence within 6 months) or recurrent head and neck squamous cell carcinoma (HNSCC) and being treated at UTMB (n=10).
• Healthy sex and age matched controls (n=10.)
• Able to comprehend risks and sign a consent form.
• Fluent in English

You may not qualify if…

• Significant renal or heart disease or any acute metabolic disease.
• Evidence of hepatitis as indicated by a 3-fold increase in of 2 out of 3 liver enzymes.
• Diabetes mellitus or other untreated endocrine disease.
• Recent (within 3 months) treatment with anabolic steroids.
• Ongoing anticoagulant therapy.
• Polycystic ovary syndrome (PCOS) and/or hyperthecosis.
• Non-classical adrenal hyperplasia.
• Cushing's syndrome.
• Pregnancy.
• Hyperprolactinoma, hypothyroidism.
• Granulocyte Count below 1.5x103/µL
• Platelet Count below 150 x 103/µL
• White Blood Cell Count below 1.0x103/µL
• Hemoglobin below 8.0 g/dL
• Organ transplant, HIV, or other criteria deemed immunosuppressing by the PI or study physician.
• Any other circumstance deemed exclusionary by the PI or study physician.

Where it is running

• The University of Texas Medical Branch — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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