Acupuncture or Metformin for Insulin Resistance in Women With PCOS
Recruiting now · Phase 2
Conditions studied: Polycystic Ovary Syndrome, Insulin Resistance, Hyperandrogenism
In brief
The hypothesis is that acupuncture is equally effective as metformin (both treatments combined with lifestyle management) in improving whole body glucose homeostasis in insulin resistant women with polycystic ovary syndrome (PCOS), and that both are superior to lifestyle management alone. The investigators hypothesize that acupuncture and metformin induce ovulation and improve hyperandrogenism, as well as health related quality of life (HRQoL) and symptoms of anxiety and depression. Although equally effective (acupuncture and metformin), the investigators hypothesize that acupuncture is associated with less negative side-effects. The investigators also hypothesize that these treatments have the potential to restore epigenetic and molecular alterations in target tissues (endometrial-, adipose-, and skeletal muscle tissue) and thus have the potential to prevent the development of type 2 diabetes (T2D).
Key facts
- Study ID
- NCT02647827
- Run by
- Karolinska Institutet
- People needed
- 303
- Starts
- 2015-12-01
- Expected to finish
- 2026-06-01
- Last updated by the study team
- 2024-10-09
Who can join
Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.
Where it is running
- Peking University — Beijing, China (enrolling)
- Karolinska University Hospital — Stockholm, Sweden (enrolling)
Full record on ClinicalTrials.gov
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