Phase 2b Challenge Study With the Bioconjugate Vaccine Flexyn2a

Completed · Phase 2 · Has a placebo group

Conditions studied: Shigellosis

In brief

In this proof of concept challenge study, the bioconjugate candidate vaccine Flexyn2a will be tested for its ability to induce an immune response that protects healthy adult volunteers from infection with a wild-type Shigella flexneri 2a strain compared to subjects receiving placebo.

Key facts

Study ID

NCT02646371

Run by

LimmaTech Biologics AG

People needed

67

Starts

2015-12-01

Expected to finish

2017-07-01

Last updated by the study team

2021-01-27

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female age 18-50 years (inclusive)
• Good health, without clinically significant medical history or physical examination findings.
• Negative serum pregnancy test at screening, and negative urine before each vaccination and before challenge for female subjects of childbearing potential.
• Females of childbearing potential must agree to avoid pregnancy by use of effective contraception. Abstinence is not acceptable as effective contraception. Female subjects unable to bear children must have this documented (e.g. tubal ligation or hysterectomy).
• Willingness to participate in the study after all aspects of the protocol have been explained and written informed consent obtained.
• Completion of a training session and demonstrated comprehension of the protocol procedures, knowledge of Shigella-associated illness, and a passing score of 70% or better on a written examination.
• Availability for the study duration, including all planned follow-up visits.
• Willingness to refrain from participating in other studies of investigational products until completion of the last study visit.

You may not qualify if…

• Women currently nursing.
• Presence of a significant medical or psychiatric condition which in the opinion of the investigator precludes participation in the study.
• Clinically significant abnormalities in screening hematology or serum chemistry as determined by PI or PI in consultation with the research monitor and sponsor.
• Presence in the serum of HIV antibody, HBs-Ag, or HCV antibody (if confirmed positive by HepC confirmatory test, i.e. RIBA, PCR)
• Evidence of IgA deficiency (serum IgA < 7 mg/dl or limit of detection of assay).
• Evidence of current excessive alcohol consumption or drug dependence.
• Evidence of impaired immune function.
• BMI <19 and ≥35
• Recent vaccination or receipt of an investigational product (within 30 days before vaccination and until last study visit).
• Personal history of an inflammatory arthritis.
• Positive blood test for HLA-B27.
• Personal history of irritable bowel syndrome as defined by Rome III criteria.
• Treatment with immunoglobulins or blood products within 3 months from first candidate vaccine injection.
• Regularly abnormal stool pattern (fewer than 3 per week or more than 3 per day) or loose or liquid stools
• Regular use of laxatives, antacids, or other agents to lower stomach acidity.
• Use of any medication known to affect the immune function (e.g., systemic steroids) within 30 days preceding the first vaccination or planned use during the entire study period.
• Known allergy to any of the following antibiotics: ciprofloxacin, trimethoprim-sulfamethoxazole or penicillin.
• Symptoms consistent with Traveler's Diarrhea concurrent with travel to countries where Shigella infection is endemic (most of the developing world) within two years prior to dosing, OR planned travel to endemic countries during the length of the study.
• Vaccination for or ingestion of Shigella within 3 years prior to vaccination.
• Use of antibiotics during the 7 days before vaccination and challenge
• Use of proton pump inhibitors, H2 blockers or antacids within 48 hours prior to challenge.
• Serum IgG titer to Shigella flexneri 2a LPS ≥ 2500
• Current occupation involving handling of Shigella bacteria
• History of allergy to any vaccine or to soy
• Any other criteria which, in the investigator's opinion, would compromise the ability of the subject to participate in the study, the safety of the study, or the results of the study

Where it is running

• Johns Hopkins Bloomberg School of Public Health, CIR — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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