Efficacy of Oral vs. Intravenous Acetaminophen

Completed · Phase 4

Conditions studied: Postoperative Pain

In brief

The comparative efficacy of intravenous (IV) to oral (PO-'per os') acetaminophen in the management of postoperative pain is understudied and largely unknown. In this observer blinded randomized clinical trial, investigators aim to determine the comparative efficacy of PO (preoperative) vs. IV (intraoperative) acetaminophen in a sinus surgery population.

Key facts

Study ID

NCT02643394

Run by

University of Texas Southwestern Medical Center

People needed

110

Starts

2015-08-17

Expected to finish

2018-01-15

Last updated by the study team

2020-04-21

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients aged 18 years or older
• Undergoing elective sinus surgery at Zale Lipshy Hospital

You may not qualify if…

• Inability of the patient to follow directions or comprehend either English or Spanish language.
• Disorders of the liver which would make acetaminophen contraindicated (such as hepatitis, liver failure, prior liver transplant, etc).
• Patients with chronic pain manifest by a baseline pain score > 4/10
• Chronic opioid use (>2 weeks continuously), or illicit drug abuse
• Body weight < 50 kg.
• Patients with contraindications to any of the study drugs (such as Malignant Hyperthermia susceptible, celecoxib or sulfa allergy, etc.).
• Patients who have taken analgesic medications on the morning of surgery (prior to arrival).
• Allergy to acetaminophen

Where it is running

• Zale Lipshy University Hospital — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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