Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial

Completed · Phase 4

Conditions studied: Cardiopulmonary Arrest, Respiratory Arrest

In brief

Patients who are having problems breathing sometimes require placement of a breathing tube in their mouth and windpipe. The purpose of this breathing tube is to save the patient's life. It is common to give the patient a medication to sedate him or her before the breathing tube is placed. For patients who are gravely ill two medications are commonly used: etomidate or ketamine. Both medications have risks and benefits. Researchers at UT-Southwestern Medical Center and Parkland Memorial Hospital would like to do a study to figure out which one is better for our patients.

Key facts

Study ID

NCT02643381

Run by

University of Texas Southwestern Medical Center

People needed

801

Starts

2016-06-06

Expected to finish

2020-12-01

Last updated by the study team

2021-12-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient (male or female) requiring emergency endotracheal intubation.

You may not qualify if…

• Children (<18 years old).
• Women who are known to be pregnant.
• Any patient who has been previously randomized in the EvK Trial.
• Patients who require endotracheal intubation without sedative medication. For example, patients in full cardiac arrest.
• Patients with a known allergy to ketamine or etomidate.
• Any individual wearing a MedAlert bracelet indicating that he/she has formally opted out of the EvK Trial.

Where it is running

• Parkland Hospital — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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