Interaction of Melatonin and MTNR1B Genotype on Glucose Control - Study 1

Completed · Not applicable · Has a placebo group

Conditions studied: Glucose, Circadian Rhythm, Melatonin, Genes

In brief

This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.

Key facts

Study ID

NCT02642640

Run by

Brigham and Women's Hospital

People needed

23

Starts

2016-11-01

Expected to finish

2022-03-24

Last updated by the study team

2026-02-12

Who can join

Age: 21 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body Mass Index: 20 and 35 kg/m2
• Age: 21-55 years of age
• Caucasian
• Non-smoking
• With regular sleep-wake cycle
• Passed medical and psychological screening tests

You may not qualify if…

• Acute, chronic or debilitating medical conditions
• History of neurological or psychiatric disorder
• History of sleep disorder or regular use of sleep-promoting medication
• Current prescription, herbal, or over-the-counter medication use
• Traveling across 2 or more time zones within past 3 months
• Worked night or rotating shift work within past 1 year
• Drug or alcohol dependency

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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