Altering Bicarbonate Delivery During Hemodialysis to Affect Filtration of Indoxyl Sulfate

Withdrawn before enrolling · Not applicable

Conditions studied: Renal Dialysis, Hemodialysis

In brief

This is a non randomized crossover trial investigating whether changing the pattern of bicarbonate administration during hemodialysis will result in the more efficient filtration of highly protein bound solutes. The experimental group will be dialyzed with low bicarbonate dialysate for the first half of dialysis then switched over to normal bicarbonate dialysate for the second half. The control group will be dialyzed entirely with normal bicarbonate dialysate. The two groups will switch one week late and patients will serve as their own matched controls for a completely standard dialysis and one that is split into two halves with different bicarbonate concentrations.

Key facts

Study ID

NCT02639624

Run by

NYU Langone Health

People needed

0

Starts

2016-01-01

Expected to finish

2017-07-01

Last updated by the study team

2017-07-31

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Chronic Stable Dialysis for at least 6 months

You may not qualify if…

• Patients with serum potassium concentration below 4.0 mEq/L on previous monthly lab test or corrected serum calcium below 8.5 mEq/L
• Hospitalization within the past 12 months
• Adults unable to consent
• Children
• Pregnant women
• Prisoners

Where it is running

• New York University School of Medicine — New York, New York, United States

Full record on ClinicalTrials.gov

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