Loop Diuretic Therapy in Acutely Decompensated Heart Failure

Recruiting now

Conditions studied: Acute Heart Failure

In brief

DiurHF is a prospective, multicenter, observational, study that compares continuous with intermittent infusion of furosemide in patients admitted with a diagnosis of ADHF. Previous pilot study design was planned to anticipate a larger multicenter trial able to definitively evaluate the optimal loop diuretic use strategy in patients with ADHF.

Key facts

Study ID

NCT02638142

Run by

University of Siena

People needed

370

Starts

2015-12-01

Expected to finish

2028-01-01

Last updated by the study team

2025-08-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients over 18 years;
• Patients with diagnosis of ADHF(dyspnea, orthopnea, peripheral edema or major fatigue and at least two clinical signs including rales, hepatomegaly, pulmonary congestion on chest radiography, jugular vein dilatation, or a third heart sound);
• Blood BNP > 100 pg/mL;
• ADHF: Acute Decompensated Heart Failure; BNP: B-type Natriuretic Peptide; IV: IntraVenous; LVEF: Left Ventricular Ejection Fraction.

You may not qualify if…

• Patients who receive more than 40 mg of IV furosemide;
• End-Stage renal disease or renal replacement therapy;
• Recent myocardial infarction (within thirty days of screening);
• Systolic blood pressure < 80 mmHg;
• Creatinine levels > 4 mg/dL;
• Patients affected by sepsis, liver diseases, inflammatory diseases or neoplastic diseases.

Where it is running

• Ospedale Madonna della Navicella — Chioggia, Venezia, Italy (enrolling)
• Azienda Ospedaliera di Padova — Padova, Italy (enrolling)
• University of Rome La Sapienza — Roma, Italy (enrolling)
• Department of Internal Medicine, Cardiovascular Diseases Unit — Siena, Italy (enrolling)

Full record on ClinicalTrials.gov

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