Innate Immune Response in COPD

Completed

Conditions studied: Pulmonary Disease, Chronic Obstructive, Immunity, Innate, Inflammation, Bronchitis, Chronic, Toll-Like Receptors

In brief

The purpose of this study is to determine whether the response of the immune system to bacterial components differs between patients with severe COPD compared to those with less severe COPD.

Key facts

Study ID

NCT02637219

Run by

VA Puget Sound Health Care System

People needed

30

Starts

2006-03-01

Expected to finish

2008-01-01

Last updated by the study team

2015-12-22

Who can join

Age: 50 and older, up to 89. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• post-bronchodilator FEV1/FVC <0.7
• FEV1 < 80%
• > 10 pack-years tobacco smoking
• no respiratory illnesses or prednisone or antibiotics in the last 4 weeks

You may not qualify if…

• Primary diagnosis of asthma
• > 15% change in FEV1
• Chronic inflammatory or infectious disease
• Cancer
• Autoimmune disease
• Chronic renal failure with a creatinine > 1.5
• Chronic liver disease
• Chronic antibiotic use
• Note: Due to difficulty recruiting patients after 6 participants were enrolled, the exclusion criteria were modified to allow patients with > 15% change in FEV1. The exclusion criteria were also changed to allow chronic renal failure not requiring dialysis, and non-metastatic cancer provided there was no diagnosis of lung cancer.

Where it is running

• VA Puget Sound Health Care System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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