Vedolizumab IV 300 mg in the Treatment of Fistulizing Crohn's Disease

Completed · Phase 4 · Has a placebo group

Conditions studied: Crohn's Disease

In brief

The purpose of this study is to evaluate the percentage of participants with perianal fistula healing at Week 30 in 2 different dose regimens of vedolizumab intravenous (IV) 300 milligram (mg) in participants with fistulizing Crohn's disease (CD).

Key facts

Study ID

NCT02630966

Run by

Takeda

People needed

34

Starts

2016-08-10

Expected to finish

2018-11-14

Last updated by the study team

2019-11-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements.
• The participant or, when applicable, the participant's legally acceptable representative has signed and dated a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures.
• Has a diagnosis of CD established at least 3 months prior to randomization by clinical and endoscopic evidence and corroborated by a histopathology report.
• Has a diagnosis of a minimum of 1 perianal draining fistula of at least 2 weeks duration as a complication of moderately to severely active CD, as identified on magnetic resonance image (MRI) at Screening. Other types of fistulae (enterocutaneous, abdominal) except rectovaginal fistulae are permitted, but the number of perianal draining fistulae is limited to 3.
• All countries except France: The participant, historically, had an inadequate response with, lost response to, or was intolerant to either conventional therapy or a tumor necrosis factor-alpha (TNF-α) antagonist for their underlying CD (does not require treatment failure for currently active draining fistula).
• France only: The participant, historically, failed (ie, had an inadequate response with, lost response to, or was intolerant to) infliximab for treatment of their underlying CD or fistulizing CD.
• If the participant had noncutting perianal seton placement as part of standard care, seton must be removed by Week 14 of the study.

You may not qualify if…

• Has a diagnosis of ulcerative colitis or indeterminate colitis.
• Has a perianal abscess greater than (>) 2 centimeter (cm) or an abscess that the investigator feels requires drainage based on either clinical assessment or MRI.
• Has a Crohn's Disease Activity Index (CDAI) score >400.
• Has an ileostomy, colostomy, or known fixed symptomatic stenosis of the intestine.
• Has significant anal or rectal stenosis.
• Has active or latent tuberculosis (TB), regardless of treatment history.
• Has evidence of active Clostridium difficile (C. difficile) infection or is having treatment for C. difficile infection or other intestinal pathogens during Screening.
• Has current rectovaginal fistula.
• Currently has more than 3 draining perianal fistulae. Note: Other protocol-defined inclusion/exclusion criteria may apply

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States
• Texas Digestive Disease Consultants — Southlake, Texas, United States
• Virginia Mason Medical Center — Seattle, Washington, United States
• University of Calgary — Calgary, Alberta, Canada
• GIRI (GI Research Institute) — Vancouver, British Columbia, Canada
• CHRU de Lille - Hopital Claude Huriez — Lille, France
• Hopital l'Archet II — Nice, France
• CHU de Rennes - Hopital de Pontchaillou — Rennes, France
• Hopital de Brabois — Vandœuvre-lès-Nancy, France
• Azienda Ospedaliera S. Orsola-Malpighi — Bologna, Italy
• Istituto Clinico Humanitas IRCCS — Milan, Italy
• Academic Medical Center — Amsterdam, Netherlands
• Leids Universitair Medisch Centrum — Leiden, Netherlands
• Erasmus MC — Rotterdam, Netherlands
• Hospital Clinic Barcelona — Barcelona, Spain
• Hospital Universitario y Politecnico La Fe — Valencia, Spain
• Nottingham University Hospitals NHS Trust — Nottingham, United Kingdom
• John Radcliffe Hospital — Oxford, United Kingdom

Full record on ClinicalTrials.gov

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