Effect of Blueberries on Bone Turnover

Status unconfirmed · Phase 1/Phase 2

Conditions studied: Osteoporosis, Postmenopausal, Bone Loss, Age-related

In brief

This study uses a bone labeling calcium tracer methodology to compare the dose-response effect of blueberry consumption on calcium retention and bone loss. Post-menopausal women will receive food or beverage products containing freeze-dried blueberries in the amount equivalent to 0.75 (low), 1.5 (medium), and 3 cups (high) of fresh blueberries per day over a 42-day period. The hypothesis is that the polyphenolics found in blueberries will reduce calcium loss from bones.

Key facts

Study ID

NCT02630797

Run by

Purdue University

People needed

20

Starts

2017-01-12

Expected to finish

2019-08-01

Last updated by the study team

2018-05-07

Who can join

Age: 45 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female subject is healthy
• Subject is > 4 years past the onset of natural menopause or total hysterectomy

You may not qualify if…

• History of metabolic bone disease or low trauma fractures;
• Subject taking osteoporosis treatment drugs or glucocorticoids within 6 months of the beginning of the study;
• Subjects taking bisphosphonates within 2 years of the beginning of the study;
• History of cancer, thromboembolisms, clotting disorders, uncontrolled hypertension, abnormal thyroid function, malabsorption syndrome, seizure disorders, or heart attack;
• BMI > 35 kg/m2;
• Subjects who will not comply with study interventions ;
• Subjects who will not stop taking natural product supplements of their own selection.

Where it is running

• Department of Nutrition Science Purdue University — West Lafayette, Indiana, United States

Full record on ClinicalTrials.gov

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