Multimodal Assessment of Sensory Processing and Brain Features in Patients With Chronic Orofacial Pain

Completed

Conditions studied: Toothache, Temporomandibular Joint Disorders

In brief

This proposal will investigate pain modulatory mechanisms and brain functional and structural characteristics using multiple MRI modalities in persistent dentoalveolar pain disorder (PDAP) patients with and without temporomandibular disorders (TMD). All measures from patients will be compared to painfree controls.

Key facts

Study ID

NCT02630771

Run by

University of Minnesota

People needed

39

Starts

2016-01-01

Expected to finish

2019-03-01

Last updated by the study team

2019-05-02

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age- and handedness-matched painfree controls using frequency matching to maintain similar group averages:
• No self-report of persistent pain conditions for the last 6 months;
• No diagnosis of PDAP or TMD;
• PDAP only:
• Fulfilling diagnostic criteria per Nixdorf et al., 20122
• Characteristic dentoalveolar PDAP pain cannot be increased by pressure provocation from jaw muscle trigger points (referred pain)
• PDAP with TMD:
• Fulfilling diagnostic criteria for PDAP2 and chronic TMD myalgia per Schiffman et al. 20143

You may not qualify if…

• Self-report:
• Chronic widespread pain
• Current use of opioids or other pain medications (e.g., ibuprofen/acetaminophen) that cannot be stopped <3 days prior to testing
• Conditions/diseases associated with altered pain perception: neurological (e.g., multiple sclerosis, trigeminal neuralgia) psychiatric disorders, diabetes, neoplasm and cardiovascular disorders
• Injury to hands
• Substance abuse
• MRI contraindications including pregnancy

Where it is running

• University of Minnesota School of Dentistry — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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