Topical Irrigation Therapy for CRS
Stopped early · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Rhinitis, Sinusitis
In brief
The purpose of the study is to evaluate the physiologic response of quinine-saline irrigations for acute exacerbation of uncomplicated chronic rhinosinusitis following endoscopic sinus surgery. Subjects who have previously had functional endoscopic sinus surgery with acute exacerbation of chronic rhinosinusitis will be randomized to either a quinine-saline or saline-placebo arm. The investigators will measure baseline and follow-up clinical and quality-of-life outcomes for both arms, and then compare the groups at the end of the study period. The investigators' hypothesis is that the participants in the quinine sulfate arm will perform better on all measures as compared to the control arm.
Key facts
- Study ID
- NCT02630472
- Run by
- University of Pennsylvania
- People needed
- 10
- Starts
- 2015-10-01
- Expected to finish
- 2017-05-04
- Last updated by the study team
- 2019-03-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who have undergone Functional Endoscopic Sinus Surgery (FESS)
- Purulent drainage on nasal endoscopy
- Male or female subjects, 18 years of age or older
- Patients seen at the Dept. of Otorhinolaryngology clinic at Hospital of the University of Pennsylvania (HUP), a tertiary care clinic
You may not qualify if…
- Pregnant women
- Immunocompromised patients
- Granulomatous diseases with rhinologic manifestations (Wegner's, Sarcoid, Churg-Strauss)
- Primary ciliary dyskinesia
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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