Motivated Behavior in Adults With and Without ADHD

Completed · Phase 2 · Has a placebo group

Conditions studied: ADHD

In brief

To investigate the effects of methylphenidate on motivated behavior in adults with and without ADHD

Key facts

Study ID

NCT02630017

Run by

University of Arkansas

People needed

51

Starts

2016-03-07

Expected to finish

2018-09-21

Last updated by the study team

2021-08-27

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• generally healthy
• between the ages of 18-45
• non-ADHD subjects do not meet criteria for ADHD diagnosis or any subtype as determined by the Conners Diagnostic Interview or any T-Score > 55 on Inattentive Symptoms, Hyperactive-Impulsive Symptoms, Total Symptoms or ADHD Index subscales of the CAARS.
• ADHD subjects meet criteria for a primary diagnosis of ADHD, any subtype, based on DSM-5

You may not qualify if…

• inability to attend all required experimental sessions
• significant health problems (e.g., current and uncontrolled liver, lung, or heart problems, current or past seizure disorder, serious head trauma)
• primary diagnosis of Axis I psychiatric disorders other than ADHD (e.g., depression, anxiety disorder, schizophrenia)
• meet DSM-5 criteria for substance use disorder other than nicotine in the past 12 months
• use of psychoactive medications in the past 6 months as indicated by self-report
• positive urine drug screen for drugs or positive breath alcohol concentration
• contraindications for MPH
• among women, nursing or a positive pregnancy test
• IQ < 80 on Kaufman Brief Intelligence Test, 2nd edition
• allergy to lactose
• hypertension (If subject is ≤ 40 years of age and has blood pressure over 135/85 or heart rate over 90 beats per minute. If subject is > 40 years of age and has blood pressure over 130/80 or heart rate over 88 beats per minute)
• body mass ratio > 30

Where it is running

• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Duke University — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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