Reliability of Pupil Response to Acute Pain

Stopped early

Conditions studied: Pain, Osteoarthritis

In brief

The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.

Key facts

Study ID

NCT02628314

Run by

Wake Forest University Health Sciences

People needed

20

Starts

2015-08-04

Expected to finish

2025-06-16

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (18-70)
• Pain from hip or knee arthritis of moderate intensity
• American Society of Anesthesiologists physical status 1-3

You may not qualify if…

• Inability to complete study questionnaires
• Pregnancy
• Litigation or workers compensation related to hip or knee pain
• Taking > 50 mg morphine equivalents/day
• History of Raynaud's disease of the feet
• Psychotic disorder or a recent psychiatric hospitalization
• History of eye surgery or topical eye medications that would would directly affect pupil diameter

Where it is running

• Wake Forest Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.