Serum Bupivacaine Concentration Levels After Injection of Liposomal Bupivacaine Into the Knee

Completed

Conditions studied: Anesthesia, Local

In brief

Serum levels of bupivacaine over time after peri-articular injection of a mixture of liposomal bupivacaine and plain bupivacaine during total knee arthroplasty.

Key facts

Study ID

NCT02626559

Run by

University of Utah

People needed

40

Starts

2015-11-01

Expected to finish

2016-11-01

Last updated by the study team

2016-12-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults of at least 18 years of age having a primary, unilateral total knee arthroplasty with a surgical plan to have an intra-articular injection of a mixture of 266 mg of Exparel, 125 mg of bupivacaine, 1:300,000 epinephrine, and 0.9% saline to make a total volume of 100 ml.

You may not qualify if…

• Known hepatic dysfunction or renal insufficiency (creatinine > 1.5 mg/dL);
• allergy to the study medications;
• pregnancy;
• incarceration;
• inability to communicate with the investigators;
• morbid obesity (body mass index > 40 kg/m2).

Where it is running

• Uutah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

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