Exercise and Brain Health

Status unconfirmed · Not applicable

Conditions studied: Stroke, Cardiovascular Risk Factors, Transient Ischemic Attack (TIA)

In brief

The risk of stroke and vascular dementia is high in individuals who have had a prior stroke or TIA, and in those who have vascular disease risk factors, such as high blood pressure, abnormal cholesterol, diabetes or pre-diabetes. These vascular risk factors can improve with exercise. This study will examine the impact of a 6 month, low intensity group exercise class on fitness, walking, balance, and brain health. This study will also collect fitness, walking, balance, and brain health outcome measures at baseline and post all other MERCE exercise and robotics interventions.

Key facts

Study ID

NCT02626442

Run by

Baltimore VA Medical Center

People needed

300

Starts

2013-07-01

Expected to finish

2025-01-01

Last updated by the study team

2016-11-01

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adequate language and neurocognitive function to participate in testing and training and to give adequate informed consent
• Able to rise from a chair unaided
• Completion of all regular post-stroke physical therapy (if applicable)
• Able to walk 30 feet without human assistance

You may not qualify if…

• Clinical history of
• unstable angina
• recent (< 3 months) myocardial infarction or congestive heart failure (NYHA category II)
• hemodynamically significant valvular dysfunction
• peripheral arterial obstructive disorder with claudication
• major orthopedic, chronic pain, or non-stroke neuromuscular disorders restricting exercise
• pulmonary or renal failure
• poorly controlled hypertension (>190/110), measured on at least two separate occasions
• recent hospitalization for severe disease or surgery
• severe or global receptive aphasia which confounds reliable testing and training
• Other medical condition precluding patient participation in this study as per medical judgment of study team
• Untreated major depression
• Pregnancy
• Alcohol consumption > 3 oz. liquor, or 3 x 4 oz glasses of wine, or 3 x 12 oz. beers per day, by self-report
• Dementia and other major cognitive deficits (based upon clinical evaluation)

Where it is running

• Baltimore VA Medical Center — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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