Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis
Completed
Conditions studied: Aortic Valve Stenosis
In brief
Aortic stenosis is a major cause of morbidity around the world. Progressive aortic stenosis leads to cardiac hypertrophy as a compensatory response. A maladaptive response may lead to heart failure at varying degrees of severity of aortic stenosis in individual patients. The predicting factors for the occurrence of a maladaptive response are not well defined. Therefore current medical therapy for aortic stenosis is considered insufficient and may actually cause harm. The only effective therapy for severe, symptomatic aortic stenosis is aortic valve replacement. It has been found in an experimental study that Podocan determines the degree of cardiac hypertrophy in response to pressure overload via the Wnt-pathway. The possible prognostic role of secreted circulating Wnt modulators in aortic stenosis has also recently gained attention. This project will attempt to establish the prognostic role of circulatory Podocan and Wnt modulators for maladaptive left ventricular response to aortic stenosis. This may help identify patients at particular risk to develop left ventricular dysfunction with aortic stenosis and improve understanding of the mechanisms of left ventricular remodeling in aortic stenosis. Hence, this may also later act as an important background in finding more effective therapies to prevent or delay maladaptive left ventricular response in aortic stenosis.
Key facts
- Study ID
- NCT02624934
- Run by
- Bassett Healthcare
- People needed
- 9
- Starts
- 2015-10-01
- Expected to finish
- 2020-06-01
- Last updated by the study team
- 2020-07-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 or greater
- Scheduled for Cardiac MRI
- Patients with known aortic valve area of less than 1 cm² on echocardiogram
- Able to provide informed consent
- Ambulatory and expected to be able to complete 6 minute walk test
You may not qualify if…
- Other significant (moderate or severe) valvular heart disease
- Unable to complete 6 minute walk test (ex. Wheelchair bound)
Where it is running
- Bassett Healthcare Network — Cooperstown, New York, United States
Full record on ClinicalTrials.gov
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