Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty
Withdrawn before enrolling · Phase 4
Conditions studied: Osteoarthritis, Pain, Postoperative
In brief
The purpose of this study is to compare the efficacy and duration of pain relief after total knee arthroplasty provided by a single injection of liposomal bupivacaine (EXPAREL®) versus standard bupivacaine with an adjuvant, dexamethasone when administered as a quadriceps sparing femoral nerve block and periarticular injection. It is hypothesized that liposomal bupivacaine is superior to standard bupivacaine with dexamethasone and will decrease time to discharge readiness.
Key facts
- Study ID
- NCT02624856
- Run by
- Albany Medical College
- People needed
- 0
- Starts
- 2015-11-01
- Expected to finish
- 2020-01-01
- Last updated by the study team
- 2020-01-23
Who can join
Age: 40 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients of American Society of Anesthesiologist (ASA) I-III physical class with a pre-operative diagnosis of primary osteoarthritis scheduled for elective primary total knee arthroplasty.
- Patients must be living independently at home prior to undergoing primary total knee arthroplasty with intention of discharge directly to home after hospitalization
You may not qualify if…
- Subjects will not be eligible for this trial if they have a history of allergy to a local anesthetic
- Known peripheral neuropathy
- Known connective tissue or immunological disorders
- Stroke or other known central nervous system disorders
- Renal dysfunction
- Hepatic dysfunction
- Cardiac dysfunction other than hypertension
- Pregnant subjects
- Immunosuppression
- Human immunodeficiency virus (HIV)
- Alcohol or drug abuse
- Chronic pain or opioid dependence
- Coagulopathy or those unable to comply with study requirements.
Where it is running
- Albany Medical Center — Albany, New York, United States
Full record on ClinicalTrials.gov
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