Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs

Completed · Not applicable

Conditions studied: Hypotension, Anesthesia

In brief

Patient undergoing general anesthesia in elective surgery will be assigned to receive either methohexital or propofol general anesthesia. Hypotensive events during the first 15 minutes of induction will be compared between the groups to ascertain which drug is less likely to cause a hypotensive event.

Key facts

Study ID

NCT02624050

Run by

Milton S. Hershey Medical Center

People needed

51

Starts

2016-08-01

Expected to finish

2018-01-31

Last updated by the study team

2025-01-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• treated for at least 6 weeks with ACEIs or ARB
• undergoing elective surgery under general endotracheal anesthesia
• ASA Physical Class I or II

You may not qualify if…

• BMI >45kg/m\^2
• taking both ACEI and ARB
• history of difficult intubation in the past
• require rapid sequence induction and intubation
• uncontrolled baseline blood pressure (SBP>180mmHg or DBP >110 mmHg) at anesthesia preoperative clinic visit
• contraindication to the use of propofol or methohexital
• significant coronary artery disease
• history of systolic heart failure
• history of renal failure (creatine level >2 mg/dL)

Where it is running

• Penn State Milton S Hershey Medical Ctr — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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