Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis

Stopped early · Phase 4

Conditions studied: Advanced Cancers, Malignant Pleural Effusions

In brief

The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.

Key facts

Study ID

NCT02623959

Run by

M.D. Anderson Cancer Center

People needed

3

Starts

2016-04-27

Expected to finish

2017-05-23

Last updated by the study team

2019-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Outpatients with MPE undergoing IPC placement
• Age 18 or older
• Sufficient mental capacity to answer SF-6D and Borg score questions.

You may not qualify if…

• Patients undergoing pleurodesis for benign disease (e.g., spontaneous pneumothorax)
• Inability or unwillingness to give informed consent
• Inability to perform phone call and clinical follow-up at MDACC
• Previous intrapleural therapy for MPE on the same side
• Chylous effusions associated with malignant disease
• ECOG of 4 and life expectancy </= 2 weeks
• Doxycycline allergy
• Contraindication to placement of an IPC (e.g., uncorrected coagulopathy)

Where it is running

• University of Texas MD Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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