Clinical Outcomes of Buffered vs. Non-Buffered Lidocaine

Completed · Not applicable

Conditions studied: Blood Levels of Buffered vs Non-buffered Lidocaine, Anesthetics, Local

In brief

Anecdotal reports suggest buffering lidocaine with epinephrine just before intraoral injection reduces time of onset, results in a deeper anesthetic effect, without the "sting" with injection from a low pH. Additional data are needed to establish clinical important outcomes such as the peak blood level of lidocaine as compared to the non-buffered drug combination. Clinical pilot studies are proposed as the start of a series of investigations to support or modify the use of the buffered anesthetic for intraoral procedures.

Key facts

Study ID

NCT02620683

Run by

University of North Carolina, Chapel Hill

People needed

23

Starts

2015-12-01

Expected to finish

2017-09-01

Last updated by the study team

2018-01-23

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-30 years
• ASA I
• Willingness to complete QOL instrument
• Willingness to participate in two sessions

You may not qualify if…

• Allergy to lidocaine class of anesthetic drugs
• Local anesthetic drug use in past week
• Current symptoms teeth or oral mucosa

Where it is running

• UNC School of Dentistry — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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