Effect of Mupirocin Dressings Versus Island Dressings on Surgical Site Infections in Elective Colorectal Surgery

Completed · Not applicable

Conditions studied: Surgical Site Infections

In brief

Infections at the site of surgical incisions (SSIs) are the most common infection among surgical patients. Although all patients undergoing surgical procedures are at risk for developing SSIs, colorectal surgery has had consistently had high rates of SSIs, ranging from 3-45%. These infections can increase the length of hospital stay, and increase the rate of readmissions and costs. Further research is needed to study the effects of mupirocin in general surgery. A recent study compared colorectal SSI rates between mupirocin and standard gauze surgical dressings. The results of this show that mupirocin has the greatest effect on reducing SSI rate when compared to standard gauze dressings. However, these studies have not been performed in the United States and have only been studied on a very specific patient population. The purpose of this study is to assess the rate of infections at the surgical incision after colorectal surgery when a mupirocin dressing is placed versus a standard gauze dressing without mupirocin.

Key facts

Study ID

NCT02619773

Run by

Gundersen Lutheran Medical Foundation

People needed

150

Starts

2015-11-01

Expected to finish

2018-12-01

Last updated by the study team

2019-01-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Elective Colorectal surgery
• Open and minimally invasive cases
• Partial and total Colon resections, Abdominoperineal resection, Low anterior resections, Creation/takedown of colostomy, abdominal procedures for prolapse

You may not qualify if…

• Patients with known allergies to mupirocin
• Cases in which the skin was intentionally left open at the end of surgery (secondary closure technique)
• Women who are pregnant or planning to become pregnant

Where it is running

• Gundersen Lutheran Health System — La Crosse, Wisconsin, United States

Full record on ClinicalTrials.gov

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