4D Phase Contrast MR: Hypertrophy in Liver Cancer

Stopped early · Not applicable

Conditions studied: Liver Cancer, Cancer of the Liver

In brief

The investigators hypothesize that 4Dimensional Phase Contrast Magnetic Resonance Angiography (4D PC MRA) evaluation of portal venous flow predicts underlying liver function and hypertrophic potential in patients with liver cancer presenting for portal vein embolization (PVE). 4D PC MRA may provide a non-invasive measure of liver function that could help determine which patients could safely and successfully undergo PVE and subsequent resection of tumor. By comparing 4D PC MRA results with invasive catheter measurements the investigators will validate the flow findings. Further regression/correlation analysis with functional measures of the liver (HIDA scans), volumetrics, Doppler flow analysis, histology, and outcomes will help the investigators to determine the ability of 4D PC MRA to predict functional status and hypertrophic potential of the liver prior to PVE and hepatectomy allowing for better patient selection and reduced morbidity/mortality.

Key facts

Study ID

NCT02618447

Run by

Washington University School of Medicine

People needed

10

Starts

2014-08-05

Expected to finish

2016-02-04

Last updated by the study team

2017-04-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of malignant liver tumor
• Clinically referred for portal vein embolization
• At least 18 years of age
• Willing and able to provide informed consent

You may not qualify if…

• Documented or reported contrast allergy
• Unable to receive or tolerate MRI scan after evaluation of MRI screening form
• GFR (glomerular filtration rate) < 30 on labs drawn within 6 weeks of imaging.

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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