Quetiapine for Delirium Prophylaxis in High-risk Critically Ill Patients

Completed · Phase 4

Conditions studied: Psychomotor Agitation

In brief

Scheduled, low-dose quetiapine is effective in preventing delirium in high-risk critically ill, trauma/surgical patients. Prophylaxis also reduced ventilator duration and ICU length of stay.

Key facts

Study ID

NCT02612948

Run by

University of Tennessee Graduate School of Medicine

People needed

82

Starts

2013-11-01

Expected to finish

2014-06-01

Last updated by the study team

2015-11-24

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Trauma/surgical patients admitted to the trauma/surgical ICU

You may not qualify if…

• sustained RASS of -4/-5 during the complete ICU admission
• presence of a condition preventing delirium assessment
• anticipated or known ICU length of stay of less than 48 hours
• taking antipsychotics prior to admission
• history of schizophrenia, epilepsy, parkinsonism, or levodopa treatment
• primary neurologic event/injury with GCS ≤ 9 during the first 48 hours of ICU
• current treatment with a continuous infusion neuromuscular blocking agent
• pregnancy
• screened positive for delirium upon admission to the ICU.

Where it is running

• University of Tennessee Medical Center — Knoxville, Tennessee, United States

Full record on ClinicalTrials.gov

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