Active Surveillance of Papillary Thyroid Microcarcinoma

Recruiting now · Not applicable

Conditions studied: Papillary Thyroid Microcarcinoma

In brief

The purpose of this study is to better understand the outcomes of active surveillance (observation) instead of immediate surgery, which is the current standard of care for papillary thyroid microcarcinoma (PTMC). Patients with a 1.5 cm or smaller thyroid nodule(s) with papillary thyroid carcinoma will be eligible for the study.

Key facts

Study ID

NCT02609685

Run by

Cedars-Sinai Medical Center

People needed

216

Starts

2016-05-13

Expected to finish

2030-12-01

Last updated by the study team

2026-05-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Pathologically confirmed Bethesda V or VI thyroid nodules with papillary thyroid carcinoma or high clinical suspicion, or pathologically confirmed Bethesda III or IV nodules with BRAF mutation.
• 2.0 cm or smaller nodules by ultrasonographic criteria
• Ability to understand and the willingness to sign a written informed consent and HIPAA Authorization form
• Must be able to read and write English fluently to participate in the questionnaire portion of the study

You may not qualify if…

• High-grade or poorly differentiated PTC variants
• Central or lateral neck lymphadenopathy suspicious for PTC
• Unfavorable nodule location (e.g. Near dorsal surface (by recurrent laryngeal nerve); Adjacent to trachea (risk of cartilage invasion)
• History of radiation to neck

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States (enrolling)

Full record on ClinicalTrials.gov

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