Auditory Stimulation of Slow Wave Sleep and Memory in Mild Cognitive Impairment and Older Adults
Completed · Not applicable · Has a placebo group
Conditions studied: Mild Cognitive Impairment
In brief
This study will evaluate the ability of sounds played during slow wave sleep using a phase locked loop algorithm to enhance slow wave sleep and memory in cognitively healthy older adults and in those with amnestic mild cognitive impairment.
Key facts
- Study ID
- NCT02608840
- Run by
- Northwestern University
- People needed
- 23
- Starts
- 2015-07-01
- Expected to finish
- 2018-12-31
- Last updated by the study team
- 2019-11-06
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women age ≥60 years;
- Amnestic MCI group: Diagnosis of aMCI based on change in cognition compared to the individual's previous level, impairment of episodic memory, preserved independence in functional abilities, and no evidence of impairment in social or occupational functioning;
- Healthy Older Adults Group: Intact cognitive profile based on neuropsychology testing within 1 standard deviation for age and education status.
- regular reported sleep and wake times
You may not qualify if…
- moderate-severe sleep apnea defined by apnea-hypopnea index ≥15 events/hour or periodic limb movement index ≥15/hour on the screening home sleep test;
- unstable medical or psychiatric disorder;
- currently doing rotating shift work or night work;
- history of seizures or taking medications that may lower the seizure threshold;
- current use of any sedative/hypnotics or stimulants, gabapentin, pregabalin, tricyclic antidepressants, and trazodone or other psychoactive medications that may alter slow wave sleep; however, stable (3 months or longer) use of antidepressants will be allowed.
- hearing loss
Where it is running
- Northwestern University — Chicago, Illinois, United States
Full record on ClinicalTrials.gov
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