Photoacoustic Endoscopy of Barrett's Esophagus
Completed · Early Phase 1
Conditions studied: Barrett Esophagus
In brief
Endoscopy is an important technique in medicine to diagnose internal organs. Video endoscopy has been the most common technique providing clear, real time video images of organs' surfaces. However, this technique only images the surface and cannot effectively diagnose diseased tissues that develop in endothelial tissues. Endoscopic ultrasound (EUS) has been developed to overcome this limitation, and it is widely utilized in diagnosing GI diseases. This technique can image very deep areas of organs, up to several centimeters; however, it suffers from speckle artifacts and cannot adequately provide early diagnosis of tissue abnormalities that do not show mechanical properties that differ significantly from those of normal tissues. The investigators propose that photoacoustic endoscopy (PAE), an endoscopic embodiment of the rapidly growing photoacoustic tomography (PAT) technology, can fulfill the aforementioned need.
Key facts
- Study ID
- NCT02606292
- Run by
- Washington University School of Medicine
- People needed
- 8
- Starts
- 2014-08-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2016-09-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 18 years and older.
- Patients with Barrett's esophagus scheduled for esophageal surgery.
- Patients with GERD, but without Barrett's esophagus, scheduled for esophageal surgery.
- Subjects must be able to understand and willing to sign a written informed consent form.
You may not qualify if…
- Inability to give informed consent.
- Pregnancy.
- Age less than 18 years
- Previous esophageal procedure (surgery, photodynamic therapy, argon plasma coagulation, endoscopic mucosal resection).
- Acute GI bleeding.
- Coagulopathy.
Where it is running
- Washington University School of Medicine — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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