Pituitary Function and Spontaneous Intracranial Hypotension

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Conditions studied: Hyperprolactinemia, Spontaneous Intracranial Hypotension

In brief

Previous research has identified spontaneous cerebral spinal fluid leakage as a cause for spontaneous intracranial hypotension, leading to positional headache patterns. Typical magnetic resonance imaging findings include subdural fluid collections, enhancement of pachymenginges, engorgement of venous structures, pituitary hyperemia, and sagging of the brain (SEEPS). Because pituitary hyperemia has been documented in cases of spontaneous cerebral spinal fluid leakage and is known to mimic a pituitary tumor or hyperplasia, the investigators would like to like to assess the clinical manifestations and neuroimaging abnormalities of SIH patients with regard to the pituitary gland. Specifically, the investigators are looking to analyze the compression of the pituitary stalk and conduct a systemic evaluation of pituitary function in SIH patients.

Key facts

Study ID

NCT02603549

Run by

Cedars-Sinai Medical Center

People needed

100

Starts

2015-07-01

Expected to finish

2020-12-01

Last updated by the study team

2019-01-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patients
• Age 18 years and older
• Diagnosis of SIH:
• LP
• Brain MRI (SEEPS)

You may not qualify if…

• Pregnant and post-partum females
• Nursing mothers
• Patients with potential hyperprolactinemia due to:
• Hypothyroidism,
• Chronic renal disorder
• Liver disease (including cirrhosis)
• Primary or secondary amenorrhea
• Polycystic Ovary Syndrome
• Seizure disorder
• Illicit drug use

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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