Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome

Recruiting now

Conditions studied: Childhood Obesity, Morbid Obesity

In brief

Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation. There is little information about the metabolic changes that lead to the rapid onset obesity in these children. The investigators would like to study the metabolic phenotype of these children to understand the disturbances in energy balance that lead to the rapid onset obesity.

Key facts

Study ID

NCT02602769

Run by

Columbia University

People needed

12

Starts

2015-11-01

Expected to finish

2026-12-01

Last updated by the study team

2025-10-21

Who can join

Age: 2 and older, up to 20. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children with ROHHAD syndrome

You may not qualify if…

• Children with known genetic causes of obesity

Where it is running

• Columbia University Irving Medical Center — New York, New York, United States (enrolling)
• Boston Children's Hospital — Boston, New York, United States

Full record on ClinicalTrials.gov

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