Neural Correlates of Working Memory Training for HIV Patients

Status unconfirmed · Not applicable

Conditions studied: HIV Infection

In brief

Despite potent combination antiretroviral therapy, cognitive (memory and concentration) problems continue to occur in up to 50% of HIV-infected individuals, especially in older infected individuals, and those who abuse alcohol, marijuana or psychostimulants. Since no effective treatments are available to these individuals with cognitive problems, conservative estimates indicate that the cost of care for these patients could double in the next two decades. To address this urgent problem, this study will use a comprehensive approach (cognitive tests, functional MRI and several biomarkers) to evaluate whether a novel computer-based training program would improve the brain function, especially working memory and attention, in HIV-infected and infected individuals.

Key facts

Study ID

NCT02602418

Run by

University of Hawaii

People needed

180

Starts

2012-09-01

Expected to finish

2020-05-01

Last updated by the study team

2019-10-02

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Confounding co-morbid psychiatric illness
• Confounding neurological disorders
• Abnormal screening laboratory tests (>2 SD) that might indicate a chronic medical condition (e.g. diabetes, severe cardiac, renal or liver disorders)
• Medications that might influence outcome measures
• Current or history of drug dependence within the past two years
• Positive urine toxicology screen
• Inability to read at an 8th grade level
• Other contraindications for MR studies

Where it is running

• University of Maryland School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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