NIRS Monitoring in Premature Infants

Recruiting now

Conditions studied: Hemorrhage, Premature Infants, Newborn, Hydrocephalus

In brief

This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) and/or post-hemorrhagic hydrocephalus (PHH) in comparison to newborns with hydrocephalus of a different etiology (VC) and healthy controls (HC). We hypothesize that baseline cerebral metabolic dysfunction is a better biomarker for GM-IVH and PHH severity and response to PHH treatment. This is a Boston Children's Hospital (BCH)-institutional review board(IRB) approved, multi-site study that includes collaboration with Brigham and Women's Hospital (BWH) and Beth Israel Deaconess Medical Center (BIDMC). Pei-Yi Lin receives funding from The National Institute of Health (NIH) to support the study and is the overall principal Investigator (PI) overseeing the study.

Key facts

Study ID
NCT02601339
Run by
Boston Children's Hospital
People needed
70
Starts
2015-04-01
Expected to finish
2026-12-01
Last updated by the study team
2026-03-18

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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