Peripheral Blood Stem Cell Transplantation for Hematologic Malignancies With Alpha Beta TCell and B Cell Depletion Using the CliniMACS Device
Running, not enrolling · Phase 2
Conditions studied: Hematologic Malignancies
In brief
This is a single arm pilot study for patients with hematologic malignancies with alternative donor sources receiving unrelated or partially matched related/Haploidentical mobilized peripheral stem cells (PSCs) using the CliniMACS system for Alpha Beta T cell depletion plus CD19+ B cell depletion to determine efficacy as determined by engraftment and GVHD, and one year leukemia free survival.
Key facts
- Study ID
- NCT02600208
- Run by
- Julie-An M. Talano
- People needed
- 60
- Starts
- 2015-10-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-05-01
Who can join
Age: any, up to 23. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Patient:
- Age. Patient age < 23 years. Both genders and all races eligible.
- Disease eligibility
- Leukemias/lymphomas:
- Acute myeloid leukemia, primary or secondary
- Disease status: remission or <10% bone marrow blasts
- Myelodysplasia
- Acute lymphoblastic leukemia
- Disease status: in hematologic remission
- Chronic myelogenous leukemia:
- Disease status: chronic phase, accelerated phase or blast crisis now in second chronic phase.
- Mixed lineage or biphenotypic acute leukemia
- Lymphoblastic lymphoma
- Disease status: remission
- Burkitt's lymphoma/leukemia:
- Disease status: in remission
You may not qualify if…
- Patient
- Patients who do not meet disease, organ or infectious criteria.
- No suitable donor
Where it is running
- Children's Hospital of Wisconsin — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
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