Feasibility and Safety of Functional Performance Testing in Patients Undergoing Hematopoietic Cell Transplantation
Completed
Conditions studied: Acute Myeloid Leukemia, Myelodysplastic Syndrome, Hematological Malignancy, Leukemia, Lymphoma, Myeloma
In brief
The purpose of this study is to see if exercise fitness testing is feasible and safe in persons over 21 years of age who have been diagnosed with a hematological malignancy and are scheduled to undergo a hematopoietic stem cell transplant (HCT). Assessments in this study will look at the capacity of the body before transplantation to see if these measures can help predict how patients do after transplant.
Key facts
- Study ID
- NCT02598752
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 11
- Starts
- 2015-11-01
- Expected to finish
- 2020-04-10
- Last updated by the study team
- 2020-04-16
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with MSK histologically confirmed hematologic malignancy
- Scheduled for autologous or allogenic HCT at MSKCC
- ≥21 years old
- ECOG performance status of 0 or 1
- Completion of baseline CPET
- Willing to comply with protocol related procedures
You may not qualify if…
- Any of the following absolute contraindications to cardiopulmonary exercise testing
- Acute myocardial Infarction (within 3-5 days of any planned study procedures)
- Unstable angina
- Uncontrolled arrhythmia causing symptoms or hemodynamic compromise
- Recurrent syncope
- Active endocarditis
- Acute myocarditis or pericarditis
- Symptomatic severe aortic stenosis
- Uncontrolled heart failure
- Acute pulmonary embolus or pulmonary infarction within 3 months of any planned study procedures
- Thrombosis of lower extremities
- Suspected dissecting aneurysm
- Uncontrolled asthma
- Pulmonary edema
- Respiratory failure
- Acute non-cardiopulmonary disorders that may affect exercise performance or be aggravated by exercise (i.e., infection, renal failure, thyrotoxicosis)
- Presence of any other concurrent, actively treated malignancy;
- History of any other malignancy treated within the past 3 years (other than non-melanoma skin cancer);
- Room air desaturation at rest ≤85%
- Mental impairment leading to inability to cooperate
Where it is running
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
Full record on ClinicalTrials.gov
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