Validation of Aspiration Markers in Intubated Patients

Withdrawn before enrolling · Phase 1

Conditions studied: Pneumonia, Aspiration

In brief

The goal of this interventional study is to test Quinine as marker of aspiration (endotracheal tube \[ETT\] cuff leakage) in mechanically ventilated, critically ill patients.

Key facts

Study ID

NCT02598713

Run by

Massachusetts General Hospital

People needed

0

Starts

2015-12-01

Expected to finish

2024-06-30

Last updated by the study team

2025-12-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Admission to Surgical ICUs (MGH Ellison 4 or Blake 12)
• Patients expected to be intubated for at least 48 hours or longer from the time of enrollment.

You may not qualify if…

• High PEEP requirement at enrollment (PEEP higher than 8 cmH2O)
• Diagnosis of ARDS (any severity)
• Status asthmatics
• Current or past participation in another interventional trial conflicting with the present study
• Pregnant women
• Prisoner status
• Patients who had partial or total gastrectomy.

Where it is running

• Massachussets General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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