Targeted Biopsies in Determining Response in Patients With Prostate Cancer Undergoing High-Dose-Rate Brachytherapy
Withdrawn before enrolling · Not applicable
Conditions studied: Stage III Prostate Adenocarcinoma
In brief
This pilot clinical trial studies targeted biopsies in determining response in patients with prostate cancer undergoing high-dose-rate brachytherapy (a type of radiation therapy in which radioactive material sealed in needles, seeds, wires, or catheters is placed directly into or near a tumor). Studying tumor tissue obtained before and after treatment may help doctors understand changes in a pathway that looks at how deoxyribonucleic acid (DNA) is repaired after it is damaged and to see if there are differences in the prostate tissue prior to and after starting androgen deprivation therapy.
Key facts
- Study ID
- NCT02597894
- Run by
- Jonsson Comprehensive Cancer Center
- People needed
- 0
- Starts
- 2018-03-01
- Expected to finish
- 2020-03-01
- Last updated by the study team
- 2020-07-24
Who can join
Age: 18 and older. Sex: male. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed primary adenocarcinoma of the prostate
- National Comprehensive Cancer Network (NCCN) high risk disease (cT3 or Gleason score 8-10 or prostate specific antigen [PSA] > 20)
- Not currently on ADT
- Magnetic resonance imaging (MRI) or transrectal doppler ultrasound demonstrating at least one target lesion
- Karnofsky performance status (KPS) >= 70 or Eastern Cooperative Oncology Group (ECOG) = 2
- Understands the trial and procedure and is willing and able to sign the informed consent form
You may not qualify if…
- Patient is unable to receive high dose rate prostate brachytherapy
- Patient is unable to have a MRI or transrectal ultrasound
- Refusal to sign the informed consent
- Patients who are participating in a concurrent treatment protocol
Where it is running
- UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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