Bacterial Composition and Immune Responses in the Nose and Oropharynx During Influenza Infection
Completed · Phase 1
Conditions studied: Influenza
In brief
This study will serve to determine how influenza infection alters the bacterial colonization patterns in the nasal and oropharyngeal compartments, and whether the immune response correlate with these alterations. The investigators will be determining bacterial composition and immune responses in the nose and oropharynx during influenza infection. Specific Aims Therefore, the overall aims of this study are as follows: 1. To identify baseline composition and kinetic changes in the nasal and oropharyngeal microflora and immune responses after administering intranasal live attenuated influenza virus (i.e., FluMist® vaccine) or saline mist to healthy subjects; 2. To identify nasal and oropharyngeal microbial composition and local immune responses during influenza infections and after resolution of infection, and correlate these changes with clinical outcomes.
Key facts
- Study ID
- NCT02597647
- Run by
- University of California, Los Angeles
- People needed
- 17
- Starts
- 2011-02-01
- Expected to finish
- 2014-04-01
- Last updated by the study team
- 2026-01-22
Who can join
Age: 18 and older, up to 64. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy volunteers:
- Healthy subjects between the ages of 18 and 65. Approximately half of the subjects will be female and approximately half will be male.
- Must be eligible to receive live-attenuated nasal version of the influenza vaccine.
- Must be able to provide signed and dated informed consent.
- Healthy subjects willing and able to provide oropharyngeal and nasal cavity specimens
You may not qualify if…
- Immunosuppressive conditions or medications
- chronic systemic medical illness
- infections or antibiotic use within the past 60 days
Where it is running
- UCLA — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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